Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch
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چکیده
منابع مشابه
Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch
Purine riboswitches have an essential role in genetic regulation of bacterial metabolism. This family includes the 2'-deoxyguanosine (dG) riboswitch, which is involved in feedback control of deoxyguanosine biosynthesis. To understand the principles that define dG selectivity, we determined crystal structures of the natural Mesoplasma florum riboswitch bound to cognate dG as well as to noncognat...
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Several mRNA aptamers have been identified in Mesoplasma florum that have sequence and structural features resembling those of guanine and adenine riboswitches. Two features distinguish these RNAs from established purine-sensing riboswitches. All possess shortened hairpin-loop sequences expected to alter tertiary contacts known to be critical for aptamer folding. The RNAs also carry nucleotide ...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2011
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.631